BASIC SCIENCE INVESTIGATIONS Stunning of Iodide Transport by 131I Irradiation in Cultured Thyroid Epithelial Cells
نویسندگان
چکیده
1Department of Radiation Physics, Sahlgrenska University Hospital, Göteborgs Universitet, Göteborg, Sweden; 2Institute of Anatomy and Cell Biology, Göteborgs Universitet, Göteborg, Sweden; 3Department of Oncology, Sahlgrenska University Hospital, Göteborgs Universitet, Göteborg, Sweden; 4Department of Surgery, Sahlgrenska University Hospital, Göteborgs Universitet, Göteborg, Sweden; and 5Department of Internal Medicine, Sahlgrenska University Hospital, Göteborgs Universitet, Göteborg, Sweden
منابع مشابه
Down-regulation of the sodium/iodide symporter explains 131I-induced thyroid stunning.
(131)I radiation therapy of differentiated thyroid cancer may be compromised by thyroid stunning (i.e., a paradoxical inhibition of radioiodine uptake caused by radiation from a pretherapeutic diagnostic examination). The stunning mechanism is yet uncharacterized at the molecular level. We therefore investigated whether the expression of the sodium/iodide symporter (NIS) gene is changed by irra...
متن کاملDna Damage Affecting Thyroidal Iodide Transport: an Explanation to Thyroid Stunning
III " Everything is possible but the impossible – just do it " 131 I is widely used clinically in the treatment of Graves´disease and differentiated thyroid cancer. However, cellular and molecular effects of 131 I irradiation in relation to absorbed dose are poorly documented. For instance, it is unknown what absorbed doses give rise to acute or delayed lethality, DNA damage that is fully resto...
متن کاملBASIC SCIENCE INVESTIGATIONS In Vitro Cytotoxicity of 211At-Astatide and 131I-Iodide to Glioma Tumor Cells Expressing the Sodium/Iodide Symporter
The sodium/iodide symporter (NIS) has been identified as an attractive target for cancer therapy. The efficacy of 131I-iodide for NIS-expressing tumor therapy may be limited by a combination of poor cellular retention and unfavorable physical characteristics (long physical half-life and low linear-energy-transfer [LET] radiative emissions). On the other hand, 211At-astatide is also transported ...
متن کاملDown-regulation of the Sodium/Iodide Symporter Explains
I radiation therapy of differentiated thyroid cancer may be compromised by thyroid stunning (i.e., a paradoxical inhibition of radioiodine uptake caused by radiation from a pretherapeutic diagnostic examination). The stunning mechanism is yet uncharacterized at the molecular level. We therefore investigated whether the expression of the sodium/ iodide symporter (NIS) gene is changed by irradiat...
متن کاملIs thyroid stunning a real phenomenon or just fiction?
Thyroid stunning is usually defined as decreased uptake or trapping of radioiodine 131I by normal thyroid tissue or differentiated thyroid cancer after diagnostic administration of 131I. As simple as this definition might be, it is as important to understand the mechanisms by which this phenomenon, if real, is caused. There are 2 possible explanations: Stunning may result either from a reductio...
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تاریخ انتشار 2002